Differential processing of objects under various viewing conditions in the human LOC

Grill-Spector, K. et al. (September 1999). Differential processing of objects under various viewing conditions in the human lateral occipital complex. Neuron, Vol. 24, 187-203.

This study used fMRIa techniques to investigate the brain's object-selective regions (namely the lateral occipital complex). fMRIa assumes that a group of neurons will respond to repeated presentations of a stimulus with attenuated responses. This signal reduction is presumably the result of neural fatigue from repeated exposure. Thus, "adaptation" data can be used to identify which types of stimulus are effectively treated identically by a certain region of the brain. This is especially interesting in structures further up the processing hierarchy where lower-level transformations have likely given way to more abstract, general representations of the stimuli. Researchers can then explore what properties of objects are preserved and which are transformed to a canonical representation by the time signals converge on a specific region.

First, the study sought to understand how long adaptation effects last. Time durations as long as 8 sec between matched stimuli still elicited amplitude reductions, establishing that adaptation has a fairly long-lasting effect.

Secondly, the study set out to examine which object properties were invariant within the LOC. The results indicate that the LOC is less sensitive to changes in size and position, compared to changes induced by illumination and viewpoint (rotation). In other words, it seems the LOC receives visual input which has been normalized for size and position.

fMRIa

Krekelberg, B, Boynton, G.M., & van Wezel, R.J.A. (2006). Adaptation: from single cells to BOLD signals. Trends in Neuroscience.

Functional magnetic resonance imaging adaptation (fMRIa) is an increasingly popular method which takes advantage of the brain changes which occur in response to long exposure to some evocative stimulus. If Stimulus 1 (S1) excites a certain neuronal population, repeated exposure to S1 will result in subsequently attenuated responses. This may be due to neural fatigue (i.e. the more a neuron fires, the more its subsequent responses will be reduced) or may be due to coupled hemodynamic processes. However, when S1 is followed by a unique stimulus, S2, the response amplitudes should not be attenuated as a fresh sub-population of neurons is excited. Using this technique can allow researchers to determine if the same or unique neuronal groups are involved in processing two stimuli. This paper goes on to describe the utility of the technique in examination of the visual system, particularly orientation, motion, and face detection. It also stresses the importance of adaptation timescale in experimental design.